Jul., 2003—Present, Professor in Medicinal Chemistry, Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, ChinaApr., 2007—Apr. 2008, Postdoctoral Visiting Scholar in Chemical Biology, University of Wisconsin-Madison, USA

　　Sep., 2000—Jul., 2003, Ph. D in Organic Chemistry, Chengdu Institute of Organic Chemistry, the Chinese Academy of Sciences (CAS), Chengdu, China

　　Sep., 1997—Jul., 2000, M. S. in Natural Products Chemistry, Chengdu Institute of Biology, the Chinese Academy of Sciences, Chengdu, China

　　Sep., 1993—Jul., 1997, B. S. in Biology, School of Life Science, Southwest Normal University (SWNU), Chongqi, China

1)Biosynthesis and Biotransformation of Natural Drugs and 2) Discovery and Synthesis of Natural Drug Leads

　　1. Yun Yang, Wei Li, Jing Pang, Liangzhen Jiang, Xixing Qu, Xiang Pu, Guolin Zhang, and Yinggang Luo*. Bifunctional Cytochrome P450 Enzymes Involved in Camptothecin Biosynthesis. ACS Chemical Biology 2019, 14, 1091-1096.

　　2. Xiang Pu*, Cheng-Rui Zhang, Lin Zhu, Qi-Long Lia, Qian-Ming Huang, Li Zhang, and Yinggang Luo*. Possible clues for camptothecin biosynthesis from the metabolites in camptothecin-producing plants. Fitoterapia 2019, 134, 113-128.

　　3. Wei Li, Yun Yang, Chong Qiao, Guolin Zhang, and Yinggang Luo*. Functional characterization of phenylalanine ammonia-lyase- and cinnamate 4-hydroxylase-encodiing genes from Lycoris radiata, a galanthamine-producing plant, International Journal of Biological Macromolecules, 2018, 117, 1264-1279.

　　4. Jinzhi Zhao, Yun Yang, Mengyao Yu, Ke Yao, Xia Luo, Huayi Qi, Guolin Zhang*, and Yinggang Luo*. Lanostane-type C31 triterpenoid derivatives from the fruiting bodies of cultivated Fomitopsis palustris. Phytochemistry 2018, 152, 10-21

　　5. Yun Yang, Xiang Pu, Xixing Qu, Fei Chen, Guolin Zhang, and Yinggang Luo*. Enhanced production of camptothecin and biological preparation of N1-acetylkynuramine in Camptotheca acuminata cell suspension cultures. Applied Microbiology and Biotechnology 2017, 101 (10), 4053-4062.

　　6. Fei Chen, Wei Li, Liangzhen Jiang, Xiang Pu, Yun Yang, Guolin Zhang, and Yinggang Luo*. Functional characterization of a geraniol synthase-encoding gene from Camptotheca acuminata and its application in the production of geraniol in Escherichia coli. Journal of Industrial Microbiology & Biotechnology 2016, 43 (9), 1281-1292.

　　7. Guoyong Luo, Qi Ye, Baowen Du, Fei Wang, Guolin Zhang*, and Yinggang Luo*. Iridoid glucosides and diteropenoids from Caryopteris glutinosa. Journal of Natural Products 2016, 79 (4), 886-893.

　　8. Xiang Pu, Fei Chen, Yun Yang, Xixing Qu, Guolin Zhang, and Yinggang Luo*. Isolation and characterization of Paenibacillus polymyxa LY214, a camptothecin-producing endophytic bacterium from Camptotheca acuminata. Journal of Industrial Microbiology & Biotechnology 2015, 42, 1197-1202.

　　9. Xixing Qu, Xiang Pu, Fei Chen, Yun Yang, Lixia Yang, Guolin Zhang, and Yinggang Luo*. Molecular cloning, heterologous expression, and functional characterization of an NADPH-cytochrome P450 reductase gene from Camptotheca acuminata, a camptothecin-producing plant. PLoS ONE 2015, 10 (8), e0135397. doi: 10.1371/journal.pone.0135397.

　　10. Guoyong Luo, Min Zhou, Qi Ye, Yan Liu, Jian Gu, Tianfang Huang, Guo-lin Zhang*, and Yinggang Luo*. Dimeric 2-Arylbenzofurans and Polyisoprenylated Flavanones from Sophora tonkinensis. Fitoterapia 2014, 99, 21-27.

　　11. Yinggang Luo*, Xiang Pu, Guoyong Luo, Min Zhou, Qi Ye, Yan Liu, Jian Gu, Huayi Qi, Guo-you Li, and Guo-lin Zhang*. Nitrogen-containing Dihydro-b-agarofuran Derivatives from Tripterygium wilfordii. Journal of Natural Products 2014, 77 (7), 1650-1657.

　　12. Xiang Pu, Xixing Qu, Fei Chen, Jinku Bao, Guolin Zhang*, and Yinggang Luo*. Camptothecin-producing Endophytic Fungus Trichoderma atroviride LY357: Isolation, Identification, and Fermentation Conditions Optimization for Camptothecin Production. Applied Microbiology and Biotechnology 2013, 97 (21), 9365-9375.

　　13. Shou-Zheng Tian, Xiang Pu, Guoyong Luo, Li-Xing Zhao, Li-Hua Xu, Wen-Jun Li, and Yinggang Luo*. Isolation and Characterization of New p-Terphenyls with Antifungal, Antibacterial, and Antioxidant Activities from Halophilic Actinomycete Nocardiopsis gilva YIM 90087. Journal of Agricultural and Food Chemistry 2013, 61 (12), 3006-3012.

　　14. Yinggang Luo, Min Zhou, Qi Ye, Qiang Pu, and Guolin Zhang*. Dihydroagarofuran derivatives from the dried roots of Tripterygium wilfordii. Journal of Natural Products 2012, 75 (1), 98-102.

　　15. Yinggang Luo*, Guangzhou Li, Guoyou Li, Jufang Yan, Jinhai Yi, and Guolin Zhang. Discovery and identification of 2-phenylethyl 2,6-dihydroxybenzoate as a natural lipid-lowering lead. Planta Medica 2011, 77 (18), 2047-2049.

　　16. Jianyu Zhao, Min Zhou, Yan Liu, Guolin Zhang, and Yinggang Luo*. Chromones and coumarins from the dried fructus of Cnidium monnieri. Fitoterapia 2011, 82, 767-771.

　　17. Sijiu Liu, Zhihong Yu, Xiao Yu, Sheng-Xiong Huang, Yinggang Luo, Li Wu, Zhenyun Yang, Lina Wang, Andrea Gunawan, Rebecca J. Chan, Ben Shen, and Zhong-Yin Zhang*. SHP2 is a Target of the Immunosuppressant Tautomycetin. Chemistry & Biology 2011, 18 (1), 101-110.

　　18. Jianya Ling, Geoffrey P. Horsman, Sheng-Xiong Huang, Yinggang Luo, Shuangjun Lin, and Ben Shen*. Enediyne Antitumor Antibiotic Maduropeptin Biosynthesis Featuring a C-Methyltransferase That Acts on a CoA-Tethered Aromatic Substrate. Journal of the American Chemical Society 2010, 132 (36), 12534-12536.

　　19. Yinggang Luo, Wenli Li, Jianhua Ju, Qiuping Yuan, Noel R. Peters, F. Michael Hoffmann, Sheng-Xiong Huang, Tim S. Bugni, Scott Rajski, Hiroyuki Osada and Ben Shen*. Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis. Journal of the American Chemical Society 2010, 132 (19), 6663-6671.

　　20. Heather A. Cooke, Elizabeth L. Guenther, Yinggang Luo, Ben Shen and Steven D. Bruner*. Molecular basis of substrate promiscuity for the SAM-dependent O-methyltransferase NcsB1, involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. Biochemistry 2009, 48 (40), 9590-9598.

　　21. Guoyou Li, Tao Yang, Yinggang Luo, Xiaozhen Chen, Dongmei Fang, and Guolin Zhang*. Brevianamide J, A New Indole Alkaloid Dimer from Fungus Aspergillus versicolor. Organic Letters 2009, 11 (16), 3714-3717.

　　22. Joel T. Adler, Mackenzie Cook, Yinggang Luo, Susan C. Pitt, Jianhua Ju, Wenli Li, Ben Shen, Muthusamy Kunnimalaiyaan and Herbert Chen*. Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3 beta. Molecular Cancer Therapeutics 2009, 8 (4), 914-920.

　　23. Wenli Li, Yinggang Luo, Jianhua Ju, Scott R. Rajski, Hiroyuki Osada, and Ben Shen*. Characterization of the tautomycetin biosynthetic gene cluster from Streptomyces griseochromogenes provides new insight into dialkylmaleic anhydride biosynthesis. Journal of Natural Products 2009, 72 (3), 450-459.

　　24. Feiyan Tao, Yinggang Luo*, Qingchun Huang, Yan Liu, Bogang Li, Guolin Zhang. Facile synthese of L-b-haloalanine derivatives from L-cysteine or L-cystine. Amino Acids 2009, 37 (4), 603-607.

　　25. Scott N. Pinchot, Joel T. Adler, Yinggang Luo, Jianhua Ju, Wenli Li, Ben Shen, Muthusamy Kunnimalaiyaan, Herbert Chen*. Tautomycin suppresses growth and neuroendocrine hormone markers in carcinoid cells through activation of the Raf-1 pathway. American Journal of Surgery 2009, 197 (3), 313–319.

　　26. Scott N. Pinchot, Joel T. Adler, Yinggang Luo, Jianhua Ju, Wenli Li, Ben Shen*, Muthusamy Kunnimalaiyaan, Herbert Chen*. Tautomycetin suppresses carcinoid tumor growth and bioactive hormone production through inactivation of glycogen synthase kinase-3 beta. Journal of the American College of Surgeons 2008, 207 (3), S103-S104.

　　27. Yinggang Luo, Shuangjun Lin, Jian Zhang, Heather A. Cooke, Steven D. Bruner, and Ben Shen*. Regiospecific O-Methylation of Naphthoic Acids Catalyzed by NcsB1, an O-Methyltransferase Involved in the Biosynthesis of the Enediyne Antitumor Antibiotic Neocarzinostatin. The Journal of Biological Chemistry 2008, 283, 14694-14702.

　　28. Yihua Chen, Yinggang Luo, Jianhua Ju, Evelyn Wendt-Pienkowski, Scott R. Rajski, Ben Shen*. Identification of Fredericamycin E from Streptomyces griseus: Insights into Fredericamycin A Biosynthesis Highlighting Carbaspirocycle Formation. Journal of Natural Products 2008, 71, 431-437.

　　29. Yinggang Luo*, Zhiheng He, Hongjuan Li, 2-Aryl Benzofurans and Their Derivatives from Seeds of Styrax macranthus, Fitoterapia 2007, 78 (3), 211-214.