张国林 职 务: 职 称:研究员 学 历:博士研究生
电 话:028-82890333 传 真:028-82890288 通讯地址:四川省成都市人民南路四段九号,中科院成都生物所
邮政编码:610041 电子邮件:zhanggl@cib.ac.cn

个人简历

      1. 大学以上学历

      1980.09-1984.07 四川大学化学系,获理学学士学位

      1984.09-1987.07 兰州大学化学系有机合成专业,获理学硕士学位

      导师:李裕林、潘鑫复教授

      1990.09-1993.09 波恩大学数学——自然科学学院药物研究所,获理学博士学位

      导师:Prof.Gerhard Ruecker,

      Prof.Eberhard Breitmaier

      2. 主要科研工作经历

      1987.07-1990.09 中国科学院成都生物研究所,从事植物化学研究,助研(1989.07)

      1993.09-1994.12 波恩大学数学——自然科学学院药物研究所,从事抗肿瘤活性天然产物的研究

      1995.01-1996.11 北京大学化学与分子工程学院,有机化学研究所,博士后,从事天然有机化学的研究。导师:邢其毅 院士

      1996.11- 中国科学院成都生物研究所从事天然药物化学的研究,研究员(1998.3-)、博士生导师(1999-),天然产物中心主任(2002-2008),副所长(2008.4-2015.10)

研究方向

      药物化学、药理学

社会任职及荣誉(含获奖)

      学术兼职

      a.《天然产物研究与开发》,编委

      b.《应用与环境生物学报》,副主编

      c. 《Chinese Journal of Natural Medicines》(SCI),编委

      d. 《Journal of Asian Natural Products Research》(SCI),编委,

      d. 《Natural Products Research and Prospecting》,编委

      e. 《African Journal of Traditional Complementary and Alternative Medicines》

      (SCI),编委

      f. 中国植物学会植物化学和资源学专业委员会委员(2014-)

      g. 《Mongolian Journal of Chemistry》,编委(2015-)

      社会兼职

      a. 四川省知识分子联谊会,副会长(2015-)

      b. 四川省欧美同学会,四川留学人员联谊会,常务理事(2015-)

      c. 四川省科青联第四届常务理事(2013-)

      d. 四川省政协委员(2015-)

      1997 入选中国科学院“百人计划”

      1999 入选“百千万人才工程”(第一、二层次,人事部等部委)

      2001 中国科学院青年科学家奖

      2003 入选“四川省学术技术带头人”

      2004 第七届四川省青年科技奖

      2004 成都市有突出贡献的优秀专家

      2006 中国科学院优秀教师

      2006 四川省优秀回国人员

      2006 国务院政府津贴

      2013 四川省科学技术进步奖,一等奖,2013,四川省人民政府。张国林(2/9)

承担科研项目情况

      1. 国家自然科学基金面上项目,21877109,毛壳霉中新颖多聚吲哚生物碱的结构与活性,2019.01-2022.12,67.5万元,在研,主持

      2. 国家自然科学基金国际(地区)合作与交流项目,21861142007,基于天然产物的老年性疾病候选药物研究,2019.01-2022.12,160万元,在研,主持

      3. 国家自然科学基金国际(地区)合作与交流项目,21561142003,治疗老年性疾病的天然产物药物发现研究,2016.01-2018.12,250万元,已结题,主持

      4. 国家自然科学基金面上项目,21372213,苯并呋喃:基于分子内脱羧、C-O键形成的合成与芳香化酶抑制活性,2014.01-2017.12,90万元,已结题,主持

      5. 国家自然科学基金面上项目,21172214,淫羊藿苷及类似物的合成与构效关系研究,2012.01-2015.12,65万元,已结题,主持

      6. 国家自然科学基金重点项目,20932007,天然产物对雌激素合成和代谢调控机制的研究,2010.01-2013.12,200万元,已结题,主持

      7. 国家重点基础研究发展计划, 2009CB522804, 确有疗效的有毒中药科学应用关键问题的基础研究——有毒中药毒效物质基础研究(课题),2009.01-2013.12,260万元,已结题,主持

      8. 国家自然科学基金重大研究计划培育项目, 90713002,化学小分子激活干扰素JAK/STAT信号途径研究,2008.01-2010.12,60万元,已结题,主持

      9. 国家自然科学基金面上项目,20672108,N-手性季铵盐的合成,2007.01-2009.12,28万元,已结题,主持

      10. 国家自然科学基金面上项目,30572221,瓦山安息香苯并呋喃促雌激素合成作用机制及构效关系研究,2006.01-2008.12,28万元,已结题,主持

代表论著

      1. Guoyou Li, Tao Yang, Yinggang Luo, Xiaozhen Chen, Dongmei Fang, Guolin Zhang*, Brevianamide J, a new indole alkaloid dimer from fungus Aspergillus versicolor, Organic Letters, 2009, 11 (16): 3714-3717

      2. Zhijun Wu, Xiaozhen Chen, Dongmei Fang, Huayi Qi, Weijian Ren, Guolin Zhang*, Analysis of phenolic glycosides from Ilex litseaefolia using electrospray ionization quadrupole time-of-flight mass spectrometry, Rapid Commun. Mass Spectrom. 2009, 23: 3881–3885

      3. Zhijun Wu, Jianxin Pu, Limei Li, Dongmei Fang, Huayi Qi, Guoyou Li, Jianzhong Chen, Handong Sun, Guolin Zhang*, Electrospray tandem mass spectrometry of longipedlactone triterpenoids, J. Mass Spectrom. 2010, 45: 451-455.

      4. Guoyou Li, Limei Li, Tao Yang, Xiaozhen Chen, Dongmei Fang, Guolin Zhang*, Four New Alkaloids, Brevianamides O–R, from the fungus Aspergillus versicolor, Helvetica Chimia Acta, 2010, 93 (10): 2075-2080

      5. Zhijun Wu, Dongmei Fang, Dan Han, Guoyou Li, Xiaozhen Chen, Huayi Qi, Guolin Zhang*, Analysis of sesterterpenoids from Aspergillus terreus using ESI-QTOF and ESI-IT, Phytochemical Analysis, 2010, 21 (4): 374-383

      6. Chun Feng, Bogang Li, Xiaoping Gao, Huayi Qi, Guolin Zhang*, A new triterpene and an antiarrhythmic liriodendrin from Pittosporum brevicalyx, Archives of Pharmacal Research,2010, 33 (12): 1927-1932

      7. Changsong Li, Hongwei Yu, Xiaozhen Chen, Xiaoqing Wu, Guoyou Li, Guolin Zhang*, Three new eudesmanolides from Camchaya loloana, Helvetica Chimia Acta, 2011, 94 (1): 105-110

      8. Lijuan Yang, Qianfeng Chen, Fei Wang*, Guolin Zhang*,Antiosteoporotic compounds from seeds of Cuscuta chinensis, Journal of Ethnopharmacology, 2011, 135: 553–560

      9. Zhijun Wu, Dongming Sun, Jianzhong Chen, Xiaozhen Chen, Dongmei Fang, Na Li, Ping Cheng,Guolin Zhang*, Analysis of cipadesin limonoids from Cipadessa cinerascens using electrospray ionization quadrupole time-of-flight tandem mass spectrometry and quantum chemical calculations, Rapid Commnications in Mass Spectrometry, 2012, 26: 563–571

      10. Yinggang Luo, Min Zhou, Qi Ye, Guolin Zhang*, Dihydroagarofurna derivatives from dried roots of Tripterygium wilfordii, Journal of Natural Produsts, 2012, 75: 98-102

      11. Danfeng Lu, Lijuan Yang, Fei Wang*, Guolin Zhang*, Inhibitory effect of luteolin on estrogen biosynthesis in human ovarian granulosa cells by suppression of aromatase (CYP19), Journal of Agricultural and Food Chemistry, 2012, 60 (34): 8411-18.

      12. Danfeng Lu, Lijuan Yang, Qilin Li, Xiaoping Gao, Fei Wang*, Guolin Zhang*, Egonol gentiobioside and egonol gentiotrioside from Styrax perkinsiae promote the of estrogen by aromatase, European Journal of Pharmacology, 2012, 691: 275–282

      13. Guobo Xu, Limei Li, Tao Yang, Guolin Zhang*, Guoyou Li*, Chaetoconvosins A and B, Alkaloids with New Skeleton from Fungus Chaetomium convolutum, Organic Letters, 2012, 14 (23): 6052–6055

      14. Lijuan Yang, Danfeng Lu, Jiajia Guo, Xianli Meng, Guolin Zhang*, Fei Wang*,Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19),Journal of Ethnopharmacology, 2013, 145: 715-721.

      15. Puzhao Zhang, Fei Wang, Lijuan Yang, Guolin Zhang*, Pregnane alkaloids from Sarcococca hookeriana var digyna, Fitoterapia, 2013,89:143-148

      16. Yuan Lin, Fei Wang, Lijuan Yang, Ze Chun, Jinku Bao, Guolin Zhang*, Anti-inflammatory phenanthrene derivatives from stems of Dendrobium denneanum, Phytochemistry,2013, 95: 242-251

      17. Xiang Pu, Xixing Qu, Fei Chen, Jinku Bao, Guolin Zhang*, Yinggang Luo*, Endophytic fungus Trichoderma atroviride LY357: Isolation, identification, and camptothecin production, Applied Microbiology and Biotechnology, 2013, 97: 9365–9375

      18. WenChen Pu, Guan-Min Mu, GuoLin Zhang*, Chun Wang*, Copper-Catalyzed Decarboxylative Intramolecular C-O Coupling: Synthesis of 2-Arylbenzofuran from 3-Arylcoumarin, RSC Advances, 2014, 4: 903–906

      19. Zhengfu Tai, Yujiao He, Yuan Lin, Junmei Huang, Jiajia Guo, Lijuan Yang, Guolin Zhang*, Fei Wang*, Luteolin Sensitizes the Antiproliferative Effect of Interferon α/β by Activation of JAK/STAT Pathway through PKA-Mediated Inhibition of SHP-2 in cancer cells, Cell Signaling, 2014, 26: 619-628

      20. Guoyong Luo, Min Zhou, Yan Liu, Qi Ye, Jian Gu, Tianfang Huang, Guolin Zhang, Yinggang Luo*,3-Formyl-2-arylbenzofurans from the aerial parts of Itea ilicifolia,Phytochemistry Letters, 2014, 10: 19–22

      21. Jiajia Guo, Yun Yuan, Danfeng Lu, Liang Xiong, Jiangong Shi, Lijuan Yang, Xiaohong Yuan, Guolin Zhang*, Fei Wang*, Two natural products, trans-phytol and (22E)-ergosta-6,9,22-triene-3β,5α,8α-triol, inhibit the biosynthesis of estrogen in human ovarian granulosa cells by aromatase (CYP19), Toxicology and Applied Pharmacology, 2014, 279 (1): 23-32

      22. Yinggang Luo, Xiang Pu, Guoyong Luo, Min Zhou, Huayi Qi, Qi Ye, Yan Liu, Guolin Zhang*, Nitrogen-containing dihydro-β-agarofuran derivatives mined from the dried roots of Tripterygium wilfordii, Journal of Natural Products, 2014,77 (7): 1650-1657 (JUL 2014)

      23. Wenchen Pu, Yuan Lin, Jianshuo Zhang, Fei Wang, Chun Wang, Guolin Zhang*, 3-Arylcoumarins: Synthesis and potent anti-inflammatory activity, Bioorganic & Medicinal Chemistry Letters, 2014, 24: 5432-5434

      24. Qinggang Mei, Chun Wang, Weicheng Yuan, Guolin Zhang*, Selective methylation of kaempferol via benzylation and deacetylation of kaempferol acetates, Beilstein Journal of Organic Chemistry, 2015, 11: 288–293. doi:10.3762/bjoc.11.33

      25. Tian Cai, Yinggang Luo, Min Zhou, Zhijun Wu*, Dongmei Fang, Guolin Zhang?, Analysis of sesquiterpene pyridine alkaloids using ESI–MS/MS: The product ion at m/z 310 formed by an ion–dipole intermediate,International Journal of Mass Spectrometry, 2015, 376: 54-57

      26. Tian Cai, Yinggang Luo, Min Zhou, Dan Wang, Zhijun Wu*, Dongmei Fang, and Guolin Zhang*. Untargeted analysis of sesquiterpene pyridine alkaloids from the dried roots of Tripterygium wilfordii using high-performance liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 2015, 29: 965-972.

      27. Qinggang Mei, Chun Wang, Zhigang Zhao, Weicheng Yuan, Guolin Zhang*, Synthesis of icariin from kaempferol through regioselective methylation and para-Claisen-Cope rearrangement, Beilstein Journal of Organic Chemistry, 2015, 11: 1220–1225. doi:10.3762/bjoc.11.135

      28. Yujiao He, Junmei Huang, Ping Wang, Xiaofei Shen, Sheng Li, Lijuan Yang, Wanli Liu, Apichart Suksamrarn, Guolin Zhang*, Fei Wang*, Emodin potentiates the antiproliferative effect of interferon ?/? by activation of JAK/STAT pathway signaling through inhibition of the 26S proteasome, Oncotarget, 2016, 7 (4): 4664-4679.

      29. Puzhao Zhang, Yamei Zhang, Jian Gu, Guolin Zhang*, Two new alkaloids from Melodinus hemsleyanus(川山橙), Natural Product Research, 2016, 30 ( 2): 162-167.

      30. Guoyong Luo, Qi Ye, Baowen Du, Fei Wang, Guolin Zhang*, Luo Yinggang*, Iridoid glucosides and diterpenoids from Caryopteris glutinosa, Journal of Natural Products, 2016, 79: 886-893

      31. Wenchen Pu, Yun Yuan, Danfeng Lu, Xin Wang, Chun Wang, Fei Wang, Guolin Zhang*, 2-Phenylbenzo[b]furans: synthesis and promoting activity on estrogen biosynthesis,Bioorganic & Medicinal Chemistry Letters, 2016, 26: 5497-5500.

      32. Xianyan Shen, Qiang Zhou, Wei Xiong, Wenchen Pu, Guolin Zhang*, Chun Wang*, Synthesis of 5-subsituted flavonols via Algar-Flynn-Oyamada (AFO) reaction: the mechanistic implication, Tetrahedron, 2017, 73: 4822-4829

      33. Orawan Wonganan, Yujiao He, Xiaofei Shen, Kanjana Wongkrajang, Apichart Suksamrarn, Guolin Zhang*, Fei Wang*, 6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the antiproliferative effect of interferon α/β by promoting the activation of JAK/STAT signaling through the inhibition of SOCS3 in hepatocellular carcinoma cells, Toxicology and Applied Pharmacology, 2017, 336:31-39

      34. Jinzhi Zhao, Yun Yang, Mengyao Yu, Ke Yao, Xia Luo, Hua-Yi Qi, Guolin Zhang*, Yinggang Luo*, Cytotoxic Lanostane-type C31 Triterpeniod Derivatives from the Fruiting Bodies of Cultivated Fomitopsis palustris, Phytochemistry, 2018, 152:10-21