张国林 职 务: 职 称:研究员 学 历:博士研究生
电 话:028-82890996 传 真:028-82890288 通讯地址:四川省成都市人民南路四段九号,中科院成都生物所
邮政编码:610041 电子邮件:zhanggl@cib.ac.cn

个人简历

      1980.09-1984.07   四川大学化学系,获理学学士学位
      1984.09-1987.07   兰州大学化学系有机合成专业,获理学硕士学位。

      1990.09-1993.09   波恩大学数学——自然科学学院药物研究所,获理学博士学位。

      1987.07-1990.09   中国科学院成都生物研究所,助研(1989.07)

      1993.09-1994.12   波恩大学,从事抗肿瘤活性天然产物的研究

      1995.01-1996.11   北京大学化学与分子工程学院有机化学研究所,博士后

      1996.11-         中国科学院成都生物研究所从事天然药物化学的研究,研究员(1998)、博士生导师(1999)、副所长(2008)

研究方向

     天然药物(化学、化学生物学)

代表论著

      近五年发表的主要论文 

      1.           Changsong Li, Hongwei Yu, Xiaozhen Chen, Xiaoqing Wu, Guoyou Li, Guolin Zhang*, Three new eudesmanolides from Camchaya loloana, Helvetica Chimica Acta, 2011, 94 (1): 105-110 

      2.           Lijuan Yang, Qianfeng Chen, Fei Wang*, Guolin Zhang*Antiosteoporotic compounds from seeds of Cuscuta chinensis, Journal of Ethnopharmacology, 2011, 135: 553–560  

      3.           Zhijun Wu, Dongming Sun, Jianzhong Chen, Xiaozhen Chen, Dongmei Fang, Na Li, Ping Cheng*Guolin Zhang*, Analysis of cipadesin limonoids from Cipadessa cinerascens using electrospray ionization quadrupole time-of-flight tandem mass spectrometry and quantum chemical calculations, Rapid Commnications in Mass Spectrometry, 2012, 26: 563–571 

      4.           Yinggang Luo, Min Zhou, Qi Ye, Guolin Zhang*, Dihydroagarofurna derivatives from dried roots of Tripterygium wilfordii, Journal of Natural Products, 2012, 75: 98-102 

      5.           Qianfeng Chen, Xiaozhen Chen, Guoyou Li, Chun Wang, Guolin Zhang*, Two new 2-phenylbenzofurans from the bark of Styrax perkinsiae, Chinese Journal of Natural Medicine, 2012, 10 (2): 92-97 

      6.           Xiaoqing Wu, Xiaozhen Chen, Qingchun Huang, Dongmei Fang, Guoyou Li, Guolin Zhang*, Toxicity of raw and processed roots of Polygonum multiflorum, Fitoterapia, 2012, 83: 469-475 

      7.           Danfeng Lu, Lijuan Yang, Fei Wang*, Guolin Zhang*, Inhibitory effect of luteolin on estrogen biosynthesis in human ovarian granulosa cells by suppression of aromatase (CYP19), Journal of Agricultural and Food Chemistry, 2012, 60 (34): 8411-18.  

      8.           Danfeng Lu, Lijuan Yang, Qilin Li, Xiaoping Gao, Fei Wang*, Guolin Zhang*, Egonol gentiobioside and egonol gentiotrioside from Styrax perkinsiae promote the  biosynthesis of estrogen by aromatase, European Journal of Pharmacology, 2012, 691: 275–282 

      9.           Guobo Xu, Limei Li, Tao Yang, Guolin Zhang*, Guoyou Li*, Chaetoconvosins A and B, Alkaloids with new skeleton from fungus Chaetomium convolutum, Organic Letters, 2012, 14 (23): 6052–6055 

      10.         Qianfeng Chen, Lijuan Yang, Guolin Zhang*, Fei Wang*, Bioactivity-guided isolation of antiosteoporotic compounds from Ligustrum lucidum, Phytotherapy Research, 2013, 27: 973-979. 

      11.         Lijuan Yang, Danfeng Lu, Jiajia Guo, Xianli Meng, Guolin Zhang*, Fei Wang*Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19)Journal of Ethnopharmacology, 2013, 145: 715-721.  

      12.         Puzhao Zhang, Fei Wang, Lijuan Yang, Guolin Zhang*, Pregnane alkaloids from Sarcococca hookeriana var digyna, Fitoterapia, 2013, 89:143-148  

      13.         Yuan Lin, Fei Wang, Lijuan Yang, Ze Chun, Jinku Bao, Guolin Zhang*, Anti-inflammatory phenanthrene derivatives from stems of Dendrobium denneanum, Phytochemistry, 2013, 95: 242-251  

      14.         Xiang Pu, Xixing Qu, Fei Chen, Jinku Bao, Guolin Zhang, Yinggang Luo, Endophytic fungus Trichoderma atroviride LY357: Isolation, identification, and camptothecin production, Applied Microbiology and Biotechnology, 2013, 97: 93659375 

      15.         Jie Ren, Guoyou Li, Lan Shen, Guolin Zhang*, Laurance A. Nafie, Huajie Zhu*Challenges in the assignment of relative and absolute configurations of complex molecules: computation can resolve conflicts between theory and experiment, Tetrahedron, 2013, 69 (48): 10351-10356 

      16.         Wenchen Pu, Guanmin Mu, Guolin Zhang*, Chun Wang*, Copper-Catalyzed Decarboxylative intramolecular C-O coupling: Synthesis of 2-arylbenzofuran from 3-arylcoumarin, RSC Advances, 2014, 4: 903–906 

      17.          Zhengfu Tai, Yujiao He, Yuan Lin, Junmei Huang, Jiajia Guo, Lijuan Yang, Guolin Zhang*,  Fei Wang*, Luteolin Sensitizes the Antiproliferative Effect of Interferon α/β by Activation of JAK/STAT Pathway through PKA-Mediated Inhibition of SHP-2 in cancer cells, Cell Signaling, 2014, 26: 619-628 

      18.         Yuan Lin, Fei Wang, Guolin Zhang*, Natural products and their derivatives regulating the Janus kinase/signal transducer and activator of transcription pathway, Journal of Asian Natural Products, 2014, 16 (7)800-812 

      19.         Jiajia Guo, Yun Yuan, Danfeng Lu, Liang Xiong, Jiangong Shi, Lijuan Yang, Xiaohong Yuan, Guolin Zhang*, Fei Wang*, Two natural products, trans-phytol and (22E)-ergosta-6,9,22-triene-3β,5α,8α-triol, inhibit the biosynthesis of estrogen in human ovarian granulosa cells by aromatase (CYP19), Toxicology and Applied Pharmacology, 2014,  279 (1): 23-32 

      20.         Yinggang Luo, Xiang Pu, Guoyong Luo, Min Zhou, Huayi Qi, Qi Ye, Yan Liu, Guolin Zhang*, Nitrogen-containing dihydro-β-agarofuran derivatives mined from the dried roots of Tripterygium wilfordii, Journal of Natural Products, 2014,  77 (7): 1650-1657  

      21.         Wenchen Pu, Yuan Lin, Jianshuo Zhang, Fei Wang, Chun Wang, Guolin Zhang*, 3-Arylcoumarins: Synthesis and potent anti-inflammatory activity, Bioorganic & Medicinal Chemistry Letters, 2014, 24: 5432-5434 

      22.         Guoyong Luo, Yinggang Luo, Min Zhou, Jian Gu, Qi Ye, Rong Zhou, Ya Dai, Guolin Zhang*, Antioxidant compounds from ethanol extracts of bamboo (Neosinocalamus affinis) leavesJournal of Asian Natural Products Research2015, 17 (3): 248-255.  

      23.         Qinggang Mei, Chun Wang, Weicheng Yuan, Guolin Zhang*, Selective methylation of kaempferol via benzylation and deacetylation of kaempferol acetates, Beilstein Journal of Organic Chemistry, 2015, 11: 288–293. 

      24.         Puzhao Zhang, Jian Gu, Guolin Zhang*, Novel Stilbenes from Artocarpus nanchuanensis, Journal of Asian Natural Products Research2015, 17 (3): 217-223  

      25.         Tian Cai, Yinggang Luo, Min Zhou, Zhijun Wu*, Dongmei Fang, Guolin Zhang, Analysis of sesquiterpene pyridine alkaloids using ESI–MS/MS: The product ion at m/z 310 formed by an ion–dipole intermediateInternational Journal of Mass Spectrometry, 2015, 376: 54-57 

      26.         Tian Cai, Yinggang Luo, Min Zhou, Dan Wang, Zhijun Wu*, Dongmei Fang, Guolin Zhang*. Untargeted analysis of sesquiterpene pyridine alkaloids from the dried roots of Tripterygium wilfordii using high-performance liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Communications in Mass Spectrometry 2015, 29: 965-972.  

      27.         Qinggang Mei, Chun Wang, Zhigang Zhao, Weicheng Yuan, Guolin Zhang*, Synthesis of icariin from kaempferol through regioselective methylation and para-Claisen-Cope rearrangement, Beilstein Journal of Organic Chemistry, 2015, 11: 1220–1225.  

      28.         Guobo Xu, Gu He, Huanhuan Bai, Tao Yang, Guolin Zhang, Linwei Wu, Guoyou Li*, Indole alkaloids from Chaetomium globosum, Journal of Natural Products, 2015, 78: 1479?1485  

      29.         Nilubon Sornkaew, Yuan Lin, Fei Wang, Guolin Zhang, Ratchanaporn Chokchaisiri, Ailian Zhang, Kanjana Wongkrajang, Parichat Suebsakwong, Pawinee Piyachaturawat, Apichart Suksamrarn*, Diarylheptanoids of Curcuma comosa with inhibitory effects on Nitric Oxide production in Macrophage RAW 264.7 Cells, Natural Product Research, 2015, 10 (1): 89-93 

      30.         Guoyong Luo, Min Zhou, Qi Ye, Jun Mi, Dongmei Fang, Guolin Zhang*, Yinggang Luo*, Phenolic Derivatives from Hypericum japonicum, Natural Product Communications, 2015, 10 (12): 2109-2112 

      31.         Yujiao He, Junmei Huang, Ping Wang, Xiaofei Shen, Sheng Li, Lijuan Yang, Wanli Liu, Apichart Suksamrarn, Guolin Zhang*, Fei Wang*, Emodin potentiates the antiproliferative effect of interferon a/b by activation of JAK/STAT pathway signaling through inhibition of the 26S proteasome, Oncotarget, 2016, 7 (4): 4664-4679.  

      32.         Puzhao Zhang, Yamei Zhang, Jian Gu, Guolin Zhang*, Two new alkaloids from Melodinus hemsleyanus, Natural Product Research, 2016, 30 ( 2): 162-167.  

      33.         Guoyong Luo, Qi Ye, Baowen Du, Fei Wang, Guolin Zhang*, Luo Yinggang*, Iridoid Glucosides and Diterpenoids from Caryopteris glutinosa, Journal of Natural Products, 2016, 79: 886-893 

      34.         Wenchen Pu, Yun Yuan, Danfeng Lu, Xin Wang, Chun Wang, Fei Wang, Guolin Zhang*, 2-Phenylbenzo[b]furans: synthesis and promoting activity on estrogen biosynthesisBioorganic & Medicinal Chemistry Letters, 2016, 26:5497-5500 

承担科研项目情况

      1.    国家自然科学基金国际合作项目,治疗老年性疾病的天然产物药物发现研究,2016.1.1-2018.12.31在研,主持 

      2.    国家自然科学基金面上项目,苯并呋喃:基于分子内脱羧、C-O键形成的合成与芳香化酶抑制活性,2014.01-2017.12,在研,主持 

      3.    国家自然科学基金重点项目,调控雌激素合成与代谢的天然产物研究,2009.01-2013.12,已结题,主持 

      4.    国家重点基础研究发展计划(课题),确有疗效的有毒中药科学应用关键问题的基础研究——有毒中药毒效物质基础研究,2009.01- 2013.12,已结题,主持 

      5.    国家自然科学基金重大研究计划,面上项目,化学小分子激活干扰素JAK/STAT信号途径研究,2008.01-2010.12,已结题,主持 

      6.    国家自然科学基金面上项目, N-手性季铵盐的合成,2007.01-2009.12,已结题,主持 

      7.    中国科学院百人计划,1998-2001,天然药物化学,已结题,主持 

获奖及荣誉

     2001 中国科学院青年科学家奖   

     2003 入选“四川省学术技术带头人”   

     2004 第七届四川省青年科技奖   

     2006 中国科学院优秀教师   

     2006 四川省优秀回国人员   

     2006 国务院政府津贴。