王明奎 职 务: 职 称:研究员 学 历:博士研究生
电 话:028-82890821 传 真:028-85222753 通讯地址:四川省成都市科园南路93号
邮政编码:610041 电子邮件:wangmk@cib.ac.cn

个人简历

      1982-1986,成都科技大学化学系,物理化学专业,获学士学位 

      1986-1992,兰州大学化学系有机分析专业,获硕士、博士学位 

      1992-现在,中国科学院成都生物研究所,研究员 

      国外经历: 

      1994-1995,日本東レ医薬研究所,客座研究员 

      1998-1999 ,美国The University of Wisconsin-Madsion,高访学者 

      2001-2005,日本HOYA株式会社,高级研究员 

        发表期刊研究论文79篇(其中SCI期刊23篇),会议论文22篇,申请专利26项,已公开24项,授权5项。 

研究方向

      天然产物化学。 

      1、 天然产物的结构与功能的基础和应用基础研究:从药用植物或发酵液等天然来源的原料中发现新结构化合物及结构修饰;天然产物结构与活性关系研究;有机化合物的定性鉴定和定量分析。 

      2、 天然产物功能性成分的应用研究:利用药用植物或发酵液中具有活性的化合物或组分开发药品、具有特定保健功能的食品以及具有特定功能的化妆品原料。 

      3、 天然产物分离纯化工艺研究:天然来源的活性成分或组分纯化的工艺研究;高纯中药对照品或其它天然来源化合物高纯品的研发。 

社会任职及荣誉(含获奖)

    四川省植物学会理事

承担科研项目情况

    主持四川省科技基金项目“麻疯树资源综合利用研究”,应用基础研究基金“厚朴中抗糖尿病活性成分的研究”,作为主研参加973项目“中药毒性研究”,“十一五”重大专项“天然活性产物分离及分析关键技术”

代表论著

      1.    Lun Wang, Fu Li, Xin Liu, Bin Chen, Kai Yu, Ming-Kui Wang. Meroterpenoids and a Naphthoquinone from Arnebia euchroma and Their Cytotoxic Activity. Planta Medica. 2015, 81(4):320-6. (DOI: 10.1055/s-0035-1545693) (Impact Factor: 2.35) 

      2.    Lun Wang, Fu Li, Chun-Yan Yang, Ashfaq-Ahmad Khan, Xin Liu, Ming-Kui Wang. Neolignans, lignans and glycoside from the fruits of Melia toosendan. Fitoterapia, 2014, 99: 92-98. 

      3.    Wenjun He, Chunyan Yang, Mingkui Wang, Fu Li. A novel phenolic acid from the fruits of Rosa Soulieana. Natural Product Research, 2014, 28(15): 1127-1133. 

      4.    Chunyan Yang, Fu Li, Baowen Du, Bin Chen, Fei Wang, Mingkui Wang. Isolation and Characterization of New Phenolic Compounds with Estrogen Biosynthesis- Inhibiting and Antioxidation Activities from Broussonetia papyrifera Leaves. PLoS ONE, 2014, 9(4): e94198. doi:10.1371/journal.pone.0094198. 

      5.    Fu Li, Hong-Mei Pan, Xin Liu, Bin Chen, Ya-Xiong Tang, Xing-Jun Xi, Mingkui Wang. New phenanthrene glycosides from Dendrobium denneanum and their cytotoxic activity. Phytochemistry Letters, 2013, 6: 640644. 

      6.    Lun Wang, Jing Wang, Fu Li, Xin Liu, Bin Chen, Ya-Xiong Tang, Mingkui Wang. Cytotoxic Sesquiterpene Lactones from Aerial Parts of Xanthium sibiricum. Planta Medica, 2013, 79(8): 661-665. 

      7.    Xiao-Long Zhang, Lun Wang, Xin Liu, Fu Li, Kai Yu and Ming-Kui Wang. Cytotoxic Phorbol Esters of Croton tiglium. Journal of Natural Products, 2013, 76(5): 858-864. 

      8.    Chunyan Yang, Fu Li, Xiaolong Zhang, Lun Wang, Zhiqiong Zhou and Mingkui Wang. Phenolic antioxidants from Rosa soulieana flowers. Natural Product Research, 2013, 27(21): 2055-2058. 

      9.    Cheng Zhi, Wang Lun, Li Fu, Wang Ming-Kui. A New Thiazinedione Glycoside from the Fruit of Xanthium sibiricum. Chemistry of Natural Compounds, 2013, 49(5): 977-979. 

      10.  Xiao-Qiang Zhang, Fu Li*, Zhi-Gang Zhao, Xing-Li Liu, Ya-Xiong Tang, Ming-Kui Wang. Diterpenoids from the root bark of Jatropha curcas and their cytotoxic activities. Phytochemistry Letters, 2012, 5:721724. 

      11.  Fu Li, Xin Liu, Minghai Tang, Bin Chen, Lisheng Ding, Lijuan Chen, Mingkui Wang. Structure revision of hupehensis saponin F and G and characterization of new trace triterpenoid saponins from Anemone hupehensis by tandem electrospray ionization mass spectrometry. Carbohydrate Research, 2012, 353, 4956. 

      12.  Fu Li, Cui-Rong Sun, Bin Chen, Li-Sheng Ding, Ming-Kui Wang. Triterpenoid saponins from Anemone raddeana. Phytochemistry Letters, 2012, 5: 258261.