博士,研究员,博士生导师。1997年毕业于四川大学应用化学系,2006年在中科院成都有机所获得有机化学博士学位。2009年6月回国后到中科院成都生物所开展工作。现任所学术委员会委员、中国科学院大学专业学位培养指导委员会委员、中科院四川转化医学研究医院学术委员会委员。在国际核心刊物上(包括Nat. Commun.; Nucleic Acids Res.; Sci. Rep.; J. Am. Chem. Soc.; Angew. Chem. Int. Ed.,等)以通讯作者或第一作者发表学术论著80余篇,申请发明专利40余件,授权17件,部分专利正在与企业合作进行转化。
核酸化学生物学:
1. 功能核酸体外筛选和体内进化;
2. 基因检测技术;
3. 蛋白降解药物设计与合成。
2013年获“国家优秀青年科学基金”
2013年获“国家自然科学二等奖”(排名五)
2015年获“四川青年五四奖章”
2016年获“中国科学院先进工作者”
2021年获“四川省科学技术进步奖三等奖”(排名二)
国家自然科学基金委优秀青年基金项目;国家自然科学基金面上项目;国家重大科技专项;中德中心-中德双边合作项目;四川省青年科技创新研究团队专项计划;成都市重大科技创新项目。
1. Han, M.; Zhang, S. Q.; Cui, X.; Wang, Q. W.; Li, G. X.*; Tang, Z.*, Chiral Phosphoric Acid Catalyzed Enantioselective Desymmetrization of 1,4-Dihydropyridines by C(sp(3))-H Bromination. Angew. Chem.-Int. Edit. 2022. IF5年=15.311
2. Ding, S.; Chen, G.*; Wei, Y.; Dong, J.; Du, F.; Cui, X.; Huang, X.; Tang, Z.*, Sequence-specific and multiplex detection of COVID-19 virus (SARS-CoV-2) using proofreading enzyme-mediated probe cleavage coupled with isothermal amplification. Biosens. Bioelectron. 2021, 178, 113041-113041. IF5年=10.722
3. Zhang, S. Q.; Li, G. X.; Li, L.; Deng, X. F.; Zhao, G.*; Cui, X.; Tang, Z.*, Alloxan-Catalyzed Biomimetic Oxidations with Hydrogen Peroxide or Molecular Oxygen. Acs Catalysis 2020, 10 (1), 245-252. IF5年=14.413
4. Pu, Q.; Zhou, S.; Huang, X.; Yuan, Y.; Du, F.; Dong, J.; Chen, G.; Cui, X.; Tang, Z.*, Intracellular Selection of Theophylline-Sensitive Hammerhead Aptazyme. Molecular Therapy-Nucleic Acids 2020, 20, 400-408. IF5年=9.043
5. Huang, X.; Chen, R.; Sun, M.; Peng, Y.; Pu, Q.; Yuan, Y.; Chen, G.; Dong, J.; Du, F.; Cui, X.; Tang, Z.*, Frame-shifted proteins of a given gene retain the same function. Nucleic Acids Res. 2020, 48 (8), 4396-4404. IF5年=17.21
6. Ma, L. J.; Chen, S. S.; Li, G. X.*; Zhu, J.; Wang, Q. W.; Tang, Z.*, Chiral Bronsted-Acid-Catalyzed Asymmetric Oxidation of Sulfenamide by Using H2O2: A Versatile Access to Sulfinamide and Sulfoxide with High Enantioselectivity. Acs Catalysis 2019, 9 (2), 1525-1530. IF5年=14.413
7. Huang, X.; Zhao, Y.; Pu, Q.; Liu, G.; Peng, Y.; Wang, F.; Chen, G.; Sun, M.; Du, F.; Dong, J.; Cui, X.; Tang, Z.*; Mo, X., Intracellular selection of trans-cleaving hammerhead ribozymes. Nucleic Acids Res. 2019, 47 (5), 2514-2522. IF5年=17.21
8. Hu, W.; Yuan, Y.; Wang, C.-H.; Tian, H.-T.; Guo, A.-D.; Nie, H.-J.; Hu, H.; Tan, M.; Tang, Z.*; Chen, X.-H.*, Genetically Encoded Residue-Selective Photo-Crosslinker to Capture Protein-Protein Interactions in Living Cells. Chem 2019, 5 (11), 2955-2968. IF5年=27.36
9. Ding, S.; Chen, R.; Chen, G. Y.; Li, M.; Wang, J. Y.; Zou, J. W.; Du, F.; Dong, J.; Cui, X.; Huang, X.; Deng, Y.*; Tang, Z.*, One-step colorimetric genotyping of single nucleotide polymorphism using probe-enhanced loop-mediated isothermal amplification (PE-LAMP). Theranostics 2019, 9 (13), 3723-3731. IF5年=12.20
10. Chen, R.; Lu, X.; Li, M.; Chen, G.; Deng, Y.; Du, F.; Dong, J.; Huang, X.; Cui, X.; Tang, Z.*, Polymerase Chain Reaction using "V" Shape Thermal Cycling Program. Theranostics 2019, 9 (6), 1572-1579. IF5年=12.20
11. Yuan, Y.; Zhao, Y.; Chen, L.; Wu, J.; Chen, G.; Li, S.; Zou, J.; Chen, R.; Wang, J.; Jiang, F.*; Tang, Z.*, Selective tumor cell death induced by irradiated riboflavin through recognizing DNA G-T mismatch. Nucleic Acids Res. 2017, 45 (15), 8676-8683. IF5年=17.21
12. Zhao, Y. Y.; Chen, H. D.; Du, F.; Yasmeen, A.; Dong, J.; Cui, X.*; Tang, Z.*, Signal amplification of glucosamine-6-phosphate based on ribozyme glmS. Biosens. Bioelectron. 2014, 62, 337-342. IF5年=10.722
13. Wang, M. Q.; Zhang, H. F.; Zhang, W.; Zhao, Y. Y.; Yasmeen, A.; Zhou, L.; Yu, X. Q.*; Tang, Z.*, In vitro selection of DNA-cleaving deoxyribozyme with site-specific thymidine excision activity. Nucleic Acids Res. 2014, 42 (14), 9262-9269. IF5年=17.21
14. Zhao, Y. Y.; Zhou, L.; Tang, Z.*, Cleavage-based signal amplification of RNA. Nat. Commun. 2013, 4, 8. IF5年=17.76
15. Dong, J.; Cui, X.; Deng, Y.*; Tang, Z.*, Amplified detection of nucleic acid by G-quadruplex based hybridization chain reaction. Biosens. Bioelectron. 2012, 38 (1), 258-263. IF5年=10.722