孙健 职 务: 职 称:研究员 学 历:博士研究生
电 话:028-85250809 传 真:028-85250809 通讯地址:四川省成都市人民南路四段9号
邮政编码:610041 电子邮件:sunjian@cib.ac.cn

个人简历

      孙健,男,1971年出生。1992年毕业于四川大学化学系,1995年在中科院成都有机化学研究所获得硕士学位,1998年在中科院化学研究所获得博士学位,并于同年赴美国Scripps研究所从事博士后研究工作,20016月聘任美国Sunesis制药公司Research Scientist2004年回国。现任中科院成都生物研究所研究员、博士生导师、天然产物研究中心主任。主要从事有机合成方法学及其在药物发现与合成方面的应用研究,已在包括Angew. Chem. Int. Ed.等国际重要刊物上发表了SCI研究论文五十余篇,先后有8篇研究论文分别被SYNFACTSNature China杂志专题报道并作为亮点介绍,有2篇研究论文被Organic Chemistry Portal专题推荐,已申请国际发明专利5项(2项已获授权)、国内发明专利9项(5项已获授权)。所领导的研究团队已成为国际上通过三氯硅烷不对称催化还原合成手性胺研究领域最重要的研究小组之一。同时,通过方法学研究,在活性药物分子发现研究方面也取得了重要的进展,针对肿瘤和糖尿病等重大疾病,已发现五类具有新结构并具有完全自主知识产权的高活性化学实体小分子,其中两个化合物即将完成临床前相关研究。实际应用方面,也积极开展与企业的紧密合作,为企业和地方经济发展提供了技术支持。已为国家培养博士毕业生和硕士毕业生30余名,其中1名博士生获得了国家奖学金,2名博士生获得了中国科学院院长奖学金优秀奖。2010年获中科院优秀研究生导师称号。 

研究方向

社会任职及荣誉(含获奖)

承担科研项目情况

    1.国家自然科学基金重大研究计划Flavokawains类化学小分子的抗肿瘤活性及信号转导机制研究”910130062011-2013

    2.国家自然科学基金面上项目“手性双功能催化剂设计及其催化三氯硅烷不对称还原反应研究” 212722272013-2016 

    3.国家自然科学基金面上项目“手性有机小分子催化不对称直接还原肼化反应研究”209721522010-2012 

    4.省青年科学基金“新型手性有机小分子催化剂的发展及其在手性药物合成中的应用” 09ZQ026-0232009-2011 

    5.国家自然科学基金重点项目“手性有机小分子催化反应研究”207320062008-2011 

    6.国家自然科学基金面上项目“手性有机小分子路易斯碱催化亚胺不对称还原”206721072007-2009 

    7.中科院项目“不对称合成方法学及天然产物合成”2004-2008 

    8.中国科学院知识创新工程重要方向项目“植物资源药物研发分中心”KSCX2-YW-R-171 2010-2011 

    9.新药创制国家重大专项项目“天然产物中化学成分的预估分析技术和快速构建具有化学多样性和结构新颖性的天然化合物库” 2009ZX09501-0152009-2010 

    10.“重大新药创制”科技重大专项“中药化学成分库建设”2011ZX09307-0022011-2013 

    11. 四川省科技厅基础支撑计划“转化医学研究平台建设”2012SZ02192013-2015 

    12. 企业合作 “手性药物中间体合成”2012-2013 

代表论著

      (1)  X.-W. Liu, C. Wang,* Y. Yan, Y.-Q. Wang, J. Sun*, “Highly Enantioselective Hydrosilylation of 1,4-Benzooxazines:S-Chirality and C-Chirality Hybridized Catalyst Makes It Possible”, J. Org. Chem. 2013, 78, 6276-6280. 

      (2)  Z. Wang*, C. Wang, L. Zhou, J. Sun*, “L-Pipecolinic Acid Derived Lewis Base Organocatalyst for Asymmetric Reduction of N-Aryl Imines by Trichlorosilane: Effects of the Side Amide Group on Catalytic Performances”, Org. Biomol. Chem. 2013, 11, 787-797. 

      (3)  F. Pan, Z. Lei, H. Wang, H. Li, J. Sun*, Z.-J. Shi*, “Rhodium(I)-Catalyzed Redox-Economic Cross-Coupling of Carboxylic Acids with Arenes Directed by N-Containing Groups”, Angew. Chem. Int. Ed. 2013, 52, 2063-2067. 

      (4)  L. Dong, T. Fan, C. Wang, J. Sun*, “One-pot formation of chiral polysubstituted 3,4-dihydropyrans via a novel organocatalytic domino sequence involving alkynal self-condensation”, Org. Lett. 2013, 15(1), 204-207. 

      (5)  P. Zhang, C. Wang*, L. Zhou, J. Sun*, “Formation of Chiral α-Monofluorinated-β-amino Esters through Organocatalytic Asymmetric Reduction of α-Fluoro-β-enamino Esters by Trichlorosilane”, Chin. J. Chem. 2012, 30, 2636-2640. 

      (6)  X.-W. Liu, Y. Yan, Y.-Q. Wang, C. Wang, J. Sun*, “Highly Enantioselective Reduction of β-Amino Nitroolefins with a Simple N-Sulfinyl Urea as Bifunctional Catalyst”, Chem. Eur. J. 2012, 18, 9204-9207. 

      (7)  Wang Z.*, Pei D., Zhang Y., Wang C., Sun J*. “A Facile One-Pot Process for the Formation of Hindered Tertiary Amines”, Molecules 2012, 17(5), 5151-5163. 

      (8)  Z. Lei, H. Li, Y. Li, X. Zhang, K, Chen, X. Wang, J. Sun*, Z.-J. Shi*, “Extrusion of CO from Aryl Ketones: Rhodium (I)-Catalyzed C-C Bond Cleavage Directed by a Pyridine Group”, Angew. Chem. Int. Ed. 2012, 51, 2609-2694. 

      (9)  X. Cai, C. Wang, J. Sun*, “Organocatalytic Enantioselective Dipolar [3+2] Cycloaddition of Acetylenic Aldehydes with Nitrones for the Formation of Chiral 4-Isoxazolines”, Adv. Synth. Catal. 2012, 354, 359-363. 

      (10) C. Wang, F. Xie, N. Suthiwangcharoen, J. Sun*, Q. Wang*, “Tuning the optical properties of BODIPY dye through Cu(I) catalyzed azide-alkyne cycloaddition (CuAAC) reaction”, Sci. China Chem. 2012, 55, 125-130. 

      (11) An J, Gao Y, Wang J, Zhu Q, Ma Y, Wu J, Sun J*, Tang Y*. Flavokawain B induces apoptosis of non-small cell lung cancer H460 cells via Bax-initiated mitochondrial and JNK pathway. Biotechnology Letters 2012, 34(10):1781-1788. 

      (12) Zhao X, Chao Y, Wan Q, Chen X, Su P, Sun J*, Tang Y*. Flavokawain B induces apoptosis of human oral adenoid cystic cancer ACC-2 cells via up-regulation of Bim and down-regulation of Bcl-2 gene expression”, Canadian Journal of Physiology and Pharmacology 2011, 89(12): 875-883. 

      (13) Ke Cheng, Tiantian Fan, Jian Sun*, “Chiral Phosphoric Acid Catalyzed Enantioselective Allylation of Aldehydes with Allyltrichlorosilane”, Chin. J. Chem. 2011, 29, 1669-1671. 

      (14) You-Cai Xiao, Chao Wang, Yuan Yao, Jian Sun*, Ying-Chun Chen*, “Direct Asymmetric Hydrosilylation of Indoles: Combined Lewis Base and Brnsted Acid Activation”, Angew. Chem. Int. Ed. 2011, 50, 10661-10664. 

      (15) X. Wu, Y. Li, C. Wang, L. Zhou, X. Lu, J. Sun*, “Chiral Lewis Base Catalyzed Highly Enantioselective Reduction ofN-Alkyl β-Enamino Esters with Trichlorosilane and Water”, Chem. Eur. J. 2011, 17, 2846-2848. 

      (16) Y. Li, K. Cheng, X. Lu, J. Sun*, “A Facile and Efficient Approach to N-Protected-b-Sulfinylenamines via C-Sulfinylation of Enamides and Enecarbamates”, Adv. Synth. Catal. 2010, 352, 1876-1880. 

      (17) Z. Wang, Z. Li, X. Lu, J. Sun*, Chiral N-formyl amino alcohol as Lewis basic organocatalyst for enantioselective hydrosilylation of ketimines”, Chin. Sci. Bull. 2010, 55, 1726-1728. 

      (18) P. Wu, D. Lin, X. Lu, J. Sun*, “Trimethylchlorosilane-promoted aza-Mannich Reaction of enecarbamates and aldimines”, Tetrahedron Lett. 2009, 50, 7249-7251. 

      (19) D. Lin, K. Cheng, X. Lu, J. Sun*, “Methyltrichlorosilane/DMSO: A Facile and Highly Efficient Recipe for the Chlorination of Enamides and Enecarbamates”, Synlett 2009, (18), 2961-2964. 

      (20) P. Wu, Z. Wang, M. Cheng, L. Zhou, J. Sun*, “Development of Highly Enantioselective New Lewis Basic N-Formamide Organocatalysts for Hydrosilylation of Imines with an Unprecedented Substrate Profile”, Tetrahedron 2008, 64, 11304-11312. 

      (21) C. Wang, X. Wu, L. Zhou, J. Sun*, “A Highly Enantioselective Organocatalytic Method for Reduction of Aromatic N-Alkyl Ketimines”, Chem. Eur. J. 2008, 14, 8789-8792. 

      (22) D. Pei, Y. Zhang. S. Wei, M. Wang, J. Sun*, “Rationally-Designed S-Chiral Bissulfinamides as Highly Enantioselective Organocatalysts for Reduction of Ketimines”, Adv. Synth. Catal. 2008, 350, 619-623. 

      (23) P. Wu, J. Sun*, “Facile Allylation of N-Boc and N-Cbz Imines with Allyltrichlorosilane Promoted by DMF”, Syn. Commun. 2008, 38, 1003-1010. 

      (24) L. Zhou, Z. Wang, S. Wei, J. Sun*, “Evolution of Chiral Lewis Basic N-Formamide as Highly Effective Organocatalyst for Asymmetric Reduction of Both Ketones and Ketimines with an Unprecedented Substrate Scope”, Chem. Commun.2007, (28), 2977 - 2979. 

      (25) H. Chen, Y. Wang, S. Wei, J. Sun*, “L-Proline Derived Triamine as Highly Stereoselective Organocatalyst for Asymmetric Michael Addition of Cyclohexanone to Nitroolefins”, Tetrahedron: Asymmetry 2007, 18, 1308-1312. 

      (26) Z. Wang, S. Wei, C. Wang, J. Sun*, Enantioselective Hydrosilylation of Ketimines Catalyzed by Lewis Basic C2-Symmetric Chiral Tetraamide”, Tetrahedron: Asymmetry 2007, 18, 705-709. 

      (27) D. Pei, Z. Wang, S. Wei, Y. Zhang, J. Sun*, “S-Chiral Sulfinamides as Highly Enantioselective Organocatalysts”,Org. Lett. 2006, 8(25), 5913-5915. 

      (28) Z. Wang, M. Cheng, P. Wu, S. Wei, J. Sun*, “L-Piperazine-2-Carboxylic Acid Derived N-Formamide as Highly Enantioselective Lewis Basic Catalyst for Hydrosilylation of N-Aryl Imines with an Unprecedented Substrate Profile”, Org. Lett. 2006, 8(14), 3045-3048. 

      (29) Z. Wang, X. Ye, S. Wei, P. Wu, A. Zhang, J. Sun*, “A Highly Enantioselective Lewis Basic Organocatalyst for Reduction of N-Aryl Imines with Unprecedented Substrate Spectrum”, Org. Lett. 2006, 8(5), 999-1001. 

      (30) C. Cheng, J. Sun*, C. Wang, Y. Zhang, S. Wei, F. Jiang, Y.-D. Wu*, “Protonated N’-benzyl-N’-prolyl Proline Hydrazide as Highly Enantioselective Catalyst for Direct Asymmetric Aldol Reaction”, Chem. Commun. 2006, (2), 215 - 217. 

      (31) Y. Wang, S. Wei, J. Sun*, “cis-4-Pyrrolidin-1-yl-L-Proline: A Highly Stereoselective Organocatalyst for the Direct Aldol Reaction”, Synlett 2006, (19), 3319-3323. 

      (32) C. Cheng, S. Wei, J. Sun*, “Trans-4-Hydroxy-L-Proline Hydrazide-Trifluoroacetic Acid as Highly Stereoselective Organocatalyst for the Asymmetric Direct Aldol Reaction of Cyclohexanone”, Synlett 2006, (15), 2419-2422.