罗应刚 职 务: 职 称:研究员 学 历:博士研究生
电 话:028-82890813 传 真: 通讯地址:成都市人民南路四段9号
邮政编码:610041 电子邮件:yinggluo@cib.ac.cn

个人简历

      1993.9——1997.7 西南师范大学生命科学学院,获理学学士学位,生物学专业。

      1997.7——2000.7 中国科学院成都生物研究所天然产物研究中心,从事天然药物化学研究,获理学硕士学位,植物学专业。

      2000.9——2003.7 中国科学院成都有机化学研究所,从事有机化学、药物化学研究,获理学博士学位,有机化学专业。

      2003.7——现 在 中国科学院成都生物研究所天然产物研究中心,从事有机化学、药物化学研究,助理研究员(2003)、副研究员(2006)、研究员(2013)。

      2007.4——2008.4 美国威斯康星大学麦迪逊分校(School of Pharmacy, University of Wisconsin-Madison),从事次级代谢产物的组合生物合成与酶促生化反应研究,访问学者

      迄今在J. Am. Chem. Soc., J. Biol. Chem., Appl. Microbiol. Biotechnol., J. Nat. Prod., J. Agr. Food Chem., J. Ind. Microbiol. Biotechnol.等刊物上发表论文70余篇;申请发明专利8项,已获授权6项;参编《生物碱化学》、《有机化学学科前沿与展望》等专著;应邀为Journal of Natural Products, Current Medicinal Chemistry, Steroids, Food and Chemical Toxicology, Fitoterapia等国际刊物及有机化学等国内刊物审稿。 

研究方向

    1)药物生物合成与转化,2)药物先导物的发现与合成

代表论著

    1.       Yun Yang, Xiang Pu, Xixing Qu, Fei Chen, Guolin Zhang, and Yinggang Luo*. Enhanced production of camptothecin and biological preparation of N1-acetylkynuramine in Camptotheca acuminata cell suspension cultures. Applied Microbiology and Biotechnology 2017, 101 (10), 4053-4062.

    2.       Fei Chen, Wei Li, Liangzhen Jiang, Xiang Pu, Yun Yang, Guolin Zhang, and Yinggang Luo*. Functional characterization of a geraniol synthase-encoding gene from Camptotheca acuminata and its application in the production of geraniol in Escherichia coli. Journal of Industrial Microbiology & Biotechnology 2016, 43 (9), 1281-1292.

    3.       Guoyong Luo, Qi Ye, Baowen Du, Fei Wang, Guolin Zhang*, and Yinggang Luo*. Iridoid glucosides and diteropenoids from Caryopteris glutinosa. Journal of Natural Products 2016, 79 (4), 886-893.

    4.       Xiang Pu, Fei Chen, Yun Yang, Xixing Qu, Guolin Zhang, and Yinggang Luo*. Isolation and characterization of Paenibacillus polymyxa LY214, a camptothecin-producing endophytic bacterium from Camptotheca acuminata. Journal of Industrial Microbiology & Biotechnology 2015, 42, 1197-1202.

    5.       Xixing Qu, Xiang Pu, Fei Chen, Yun Yang, Lixia Yang, Guolin Zhang, and Yinggang Luo*. Molecular cloning, heterologous expression, and functional characterization of an NADPH-cytochrome P450 reductase gene from Camptotheca acuminata, a camptothecin-producing plant. PLoS ONE 2015, 10 (8), e0135397. doi: 10.1371/journal.pone.0135397.

    6.       Guoyong Luo, Min Zhou, Qi Ye, Yan Liu, Jian Gu, Tianfang Huang, Guo-lin Zhang*, and Yinggang Luo*. Dimeric 2-Arylbenzofurans and Polyisoprenylated Flavanones from Sophora tonkinensis. Fitoterapia 2014, 99, 21-27.

    7.       Yinggang Luo*, Xiang Pu, Guoyong Luo, Min Zhou, Qi Ye, Yan Liu, Jian Gu, Huayi Qi, Guo-you Li, and Guo-lin Zhang*. Nitrogen-containing Dihydro-b-agarofuran Derivatives from Tripterygium wilfordii. Journal of Natural Products 2014, 77 (7), 1650-1657.

    8.       Xiang Pu, Xixing Qu, Fei Chen, Jinku Bao, Guolin Zhang*, and Yinggang Luo*. Camptothecin-producing Endophytic Fungus Trichoderma atroviride LY357: Isolation, Identification, and Fermentation Conditions Optimization for Camptothecin Production. Applied Microbiology and Biotechnology 2013, 97 (21), 9365-9375.

    9.       Shou-Zheng Tian, Xiang Pu, Guoyong Luo, Li-Xing Zhao, Li-Hua Xu, Wen-Jun Li, and Yinggang Luo*. Isolation and Characterization of New p-Terphenyls with Antifungal, Antibacterial, and Antioxidant Activities from Halophilic Actinomycete Nocardiopsis gilva YIM 90087. Journal of Agricultural and Food Chemistry 2013, 61 (12), 3006-3012.

    10.   Yinggang Luo, Min Zhou, Qi Ye, Qiang Pu, and Guolin Zhang*. Dihydroagarofuran derivatives from the dried roots of Tripterygium wilfordii. Journal of Natural Products 2012, 75 (1), 98-102.

    11.   Yinggang Luo*, Guangzhou Li, Guoyou Li, Jufang Yan, Jinhai Yi, and Guolin Zhang. Discovery and identification of 2-phenylethyl 2,6-dihydroxybenzoate as a natural lipid-lowering lead. Planta Medica 2011, 77 (18), 2047-2049.

    12.   Jianyu Zhao, Min Zhou, Yan Liu, Guolin Zhang, and Yinggang Luo*. Chromones and coumarins from the dried fructus of Cnidium monnieri. Fitoterapia 2011, 82, 767-771.

    13.   Sijiu Liu, Zhihong Yu, Xiao Yu, Sheng-Xiong Huang, Yinggang Luo, Li Wu, Zhenyun Yang, Lina Wang, Andrea Gunawan, Rebecca J. Chan, Ben Shen, and Zhong-Yin Zhang*. SHP2 is a Target of the Immunosuppressant Tautomycetin. Chemistry & Biology 2011, 18 (1), 101-110.

    14.   Jianya Ling, Geoffrey P. Horsman, Sheng-Xiong Huang, Yinggang Luo, Shuangjun Lin, and Ben Shen*. Enediyne Antitumor Antibiotic Maduropeptin Biosynthesis Featuring a C-Methyltransferase That Acts on a CoA-Tethered Aromatic Substrate. Journal of the American Chemical Society 2010, 132 (36), 12534-12536.

    15.   Yinggang Luo, Wenli Li, Jianhua Ju, Qiuping Yuan, Noel R. Peters, F. Michael Hoffmann, Sheng-Xiong Huang, Tim S. Bugni, Scott Rajski, Hiroyuki Osada and Ben Shen*. Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis. Journal of the American Chemical Society 2010, 132 (19), 6663-6671.

    16.   Heather A. Cooke, Elizabeth L. Guenther, Yinggang Luo, Ben Shen and Steven D. Bruner*. Molecular basis of substrate promiscuity for the SAM-dependent O-methyltransferase NcsB1, involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. Biochemistry 2009, 48 (40), 9590-9598.

    17.   Guoyou Li, Tao Yang, Yinggang Luo, Xiaozhen Chen, Dongmei Fang, and Guolin Zhang*. Brevianamide J, A New Indole Alkaloid Dimer from Fungus Aspergillus versicolor. Organic Letters 2009, 11 (16), 3714-3717.

    18.   Joel T. Adler, Mackenzie Cook, Yinggang Luo, Susan C. Pitt, Jianhua Ju, Wenli Li, Ben Shen, Muthusamy Kunnimalaiyaan and Herbert Chen*. Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3 beta. Molecular Cancer Therapeutics 2009, 8 (4), 914-920.

    19.   Wenli Li, Yinggang Luo, Jianhua Ju, Scott R. Rajski, Hiroyuki Osada, and Ben Shen*. Characterization of the tautomycetin biosynthetic gene cluster from Streptomyces griseochromogenes provides new insight into dialkylmaleic anhydride biosynthesis. Journal of Natural Products 2009, 72 (3), 450-459.

    20.   Feiyan Tao, Yinggang Luo*, Qingchun Huang, Yan Liu, Bogang Li, Guolin Zhang. Facile synthese of L-b-haloalanine derivatives from L-cysteine or L-cystine. Amino Acids 2009, 37 (4), 603-607.

    21.   Scott N. Pinchot, Joel T. Adler, Yinggang Luo, Jianhua Ju, Wenli Li, Ben Shen, Muthusamy Kunnimalaiyaan, Herbert Chen*. Tautomycin suppresses growth and neuroendocrine hormone markers in carcinoid cells through activation of the Raf-1 pathway. American Journal of Surgery 2009, 197 (3), 313–319.

    22.   Scott N. Pinchot, Joel T. Adler, Yinggang Luo, Jianhua Ju, Wenli Li, Ben Shen*, Muthusamy Kunnimalaiyaan, Herbert Chen*. Tautomycetin suppresses carcinoid tumor growth and bioactive hormone production through inactivation of glycogen synthase kinase-3 beta. Journal of the American College of Surgeons 2008, 207 (3), S103-S104.

    23.   Yinggang Luo, Shuangjun Lin, Jian Zhang, Heather A. Cooke, Steven D. Bruner, and Ben Shen*. Regiospecific O-Methylation of Naphthoic Acids Catalyzed by NcsB1, an O-Methyltransferase Involved in the Biosynthesis of the Enediyne Antitumor Antibiotic Neocarzinostatin. The Journal of Biological Chemistry 2008, 283, 14694-14702.

    24.   Yihua Chen, Yinggang Luo, Jianhua Ju, Evelyn Wendt-Pienkowski, Scott R. Rajski, Ben Shen*. Identification of Fredericamycin E from Streptomyces griseus: Insights into Fredericamycin A Biosynthesis Highlighting Carbaspirocycle Formation. Journal of Natural Products 2008, 71, 431-437.

    25.   Yinggang Luo*, Zhiheng He, Hongjuan Li, 2-Aryl Benzofurans and Their Derivatives from Seeds of Styrax macranthus, Fitoterapia 2007, 78 (3), 211-214.

承担科研项目情况

      主持和主研科技部973计划,国家自然科学基金委重点项目、重大研究计划、面上项目、国际合作项目,中国科学院、四川省和成都市等各类科研项目10多项。 

获奖及荣誉