青琳森 职 务: 职 称:副研究员 学 历:博士研究生
电 话:028-82890640 传 真: 通讯地址:人民南路四段9号
邮政编码:610041 电子邮件:

个人简历

      青琳森,男,19819月生,四川南充人,执业药师,中国科学院成都生物研究所副研究员、硕士生导师。 

      教育经历: 

      1999.09 - 2003.06     华西医科大学,药学院,药学专业本科 

      2003.09 - 2006.06     四川大学,华西药学院,生药学专业硕士 

      其间:2004.06 - 2005.05       香港浸会大学,中医药学院,访问学者 

      2008.09 - 2011.06     中国科学院成都生物研究所,药物化学专业博士 

        

      工作经历: 

      2006.07 - 2008.08     成都地奥制药集团,药物研究所,助理工程师 

      2011.07 - 2013.06     中国科学院成都生物研究所,博士后 

      其间:2012.08 - 2012.11       美国杰克逊州立大学,化学系,研究助理 

      2013.7至今              中国科学院成都生物研究所,副研究员 

研究方向

      天然活性成分分析与新药研发 

社会任职及荣誉(含获奖)

      中国科学院院长优秀奖 

      四川省优秀大学毕业生 

      卢嘉锡优秀研究生奖 

      中国化学会第十六届有机分析与生物分析学术研讨会口头报告优秀奖 

承担科研项目情况

      [1]   四川省科技厅重点研发项目,《黄芪甲苷水溶性衍生物的成药性研究》,2019.1-2020.12 

      [2]   中国科学院西部青年学者(院内A类)项目,2019.1-2021.12 

      [3]   中国科学院战略生物资源服务网络计划活性天然化合物发现、评价与转化平台目,《基于多靶标的微循环改善创新药物LS-102的临床前药效学研究》,2018.8-2021.7 

      [4]   中国博士后科学基金第6批特别资助,《基于磁性纳米配体垂钓的降糖中——相关指纹图谱》,2013.6-2016.6 

      [5]   中国科学院西部博士人才培养计划,2013.1-2016.6 

      [6]   国家自然科学基金青年基金,《基于磁性纳米配体垂钓技术的降糖中药活性代谢产物研究》,2013.1-2015.12 

      [7]   中国博士后科学基金第50批面上资助,《用磁性纳米配体垂钓技术筛寻中药肝代谢物中降糖活性成份》,2011.9-2013.12 

      作为项目主要研究人员,参与包括科技部国际合作计划,国家自然科学基金面上项目、香港特区政府卫生署项目、澳门科学技术发展基金等多项课题的研究。 

        

代表论著

      发表论文(SCI一作/通讯): 

      [1]   Sun Wen-Xia, Zhang Zhi-Feng, Xie Jing, He Ying, Cheng Yong, Ding Li-Sheng, Luo Pei*, Qing Lin-Sen*. Determination of a astragaloside IV derivative LS-102 in plasma by ultra-performance liquid chromatography-tandem mass spectrometry in dog plasma and its application in a pharmacokinetic study. Phytomedicine, 2019, 53: 243-251. 

      [2]   Xue Ying, Xie Jing, Xu Xian-Shun, Yong Li, Hu Bin, Liang Jian, Li Xing-De, Qing Lin-Sen*. UPLC-QqQ/MS combined with similarity assessment of 17 nucleic acid constituents in 147 edible fungi from Sichuan Basin, China. Food Research International, 2019, 120: 577-585. 

      [3]   Qing Lin-Sen, Chen Ting-Bo, Sun Wen-Xia, Chen Li, Luo Pei, Zhang Zhi-Feng, Ding Li-Sheng. Pharmacokinetics comparison, intestinal absorption and acute toxicity assessment of a novel water-soluble astragaloside IV derivative (astragalosidic acid, LS-102). European Journal of Drug Metabolism and Pharmacokinetics, 2019, 44(2): 251-259. 

      [4]   Xue Ying, Jin Wei, Xu Xian-Shun, Yong Li, Hu Bin, Xiong Jing, Hu Xue-Mei, Qing Lin-Sen*, Xie Jing*. Quality evaluation of Tricholoma matsutake based on the nucleic acid compounds by UPLC-TOF/MS and UPLC-QqQ/MS. Molecules, 2019, 24(1): 34. 

      [5]   Xue Ying#, Qing Lin-Sen#, Yong Li, Xu Xian-Shun, Hu Bin, Tang Ming-Qing, Xie Jing. Determination of flavonoid glycosides by UPLC-MS to authenticate commercial lemonade. Molecules, 2019, 24(16): 3016. 

      [6]   Wang Qian-Long, Xie Jing, Liang Jian, Dong Geng-Ting, Ding Li-Sheng, Luo Pei*, Qing Lin-Sen*. Competitive protein binding assay of naproxen by human serum albumin functionalized silicon dioxide nanoparticles. Molecules, 2019, 24(14): 2593. 

      [7]   Xie Jing, Xiong Jing, Ding Li-Sheng, Chen Li, Zhou Hua, Liu Liang, Zhang Zhi-Feng, Hu Xue-Mei, Luo Pei*, Qing Lin-Sen*. A efficient method to identify cardioprotective components of Astragali Radix using a combination of molecularly imprinted polymers-based knockout extract and activity evaluation. Journal of Chromatography A, 2018, 1576: 10-18. 

      [8]   Chen Chu, Xue Ying, Li Qing-Miao, Wu Yan, Liang Jian, Qing Lin-Sen*. Neutral loss scan - based strategy for integrated identification of amorfrutin derivatives, new peroxisome proliferator-activated receptor gamma agonists, from Amorpha Fruticosa by UPLC-QqQ-MS/MS and UPLC-Q-TOF-MS. Journal of The American Society for Mass Spectrometry, 2018, 29(4): 685-693. 

      [9]   Xue Ying, Xu Xian-Shun, Yong Li, Hu Bin, Li Xing-De, Zhong Shi-Hong, Li Yi, Xie Jing*, Qing Lin-Sen*. Optimization of vortex-assisted dispersive liquid-liquid microextraction for the simultaneous quantitation of eleven non-anthocyanin polyphenols in commercial blueberry using the multi-objective response surface methodology and desirability function approach. Molecules, 2018, 23(11): 2921. 

      [10]             Qing Lin-Sen, Peng Shu-Lin, Liang Jian, Ding Li-Sheng. Astragalosidic acid: a new water-soluble derivative of astragaloside IV prepared using remarkably simple TEMPO-mediated oxidation. Molecules, 2017, 22(8): 1275. 

      [11]             Wang Qian-Long, Li Jie, Li Xing-De, Tao Wan-Jun, Ding Li-Sheng, Luo Pei*, Qing Lin-Sen*. An efficient direct competitive nano-ELISA for residual BSA determination in vaccines. Analytical and Bioanalytical Chemistry, 2017, 409(19): 4607-4614. 

      [12]             Wang Qian-Long, Xie Jing, Li Xing-De, Ding Li-Sheng, Liang Jian, Luo Pei*, Qing Lin-Sen*. Development of a nano-SiO2 based enzyme-linked ligand binding assay for the determination of ibuprofen in human urine. Talanta, 2017, 167: 617-622. 

      [13]             Wang Qian-Long, Li Jie, Li Xing-De, Ding Li-Sheng, Xie Jing*, Qing Lin-Sen*. A simple nano-SiO2 based ELISA method for residue detection of 2,4-dichlorophenoxyacetic acid in bean sprouts. Food Analytical Methods, 2017, 10(5): 1500-1506. 

      [14]             Xie Jing, Li Jie, Liang Jian, Luo Pei*, Qing Lin-Sen*, Ding Li-Sheng. Determination of contents of catechins in oolong teas by quantitative analysis of multi-components via a single marker (QAMS) method. Food Analytical Methods, 2017, 10(2): 363-368. 

      [15]             Qing Lin-Sen, Xue Ying, Ding Li-Sheng, Liu Yi-Ming, Liang Jian Liao, Xun A rapid study of botanical drug-drug interaction with protein by re-ligand fishing using human serum albumin-functionalized magnetic nanoparticles. Natural Product Communications. 2015, 10(12): 2161-2163. 

      [16]              Xie Jing, Liao Xun, Qing Fang-Zhu, Luo Pei, Zhang Zhi-Feng, Huang Jing*, Qing Lin-Sen*. A novel rhein-functionalized resin with application for the preconcentration of anthraquinones. Analytical Letters. 2014, 47(14): 2332-2340. 

      [17]             Qing Lin-Sen, Xue Ying, Liu Yi-Ming, Liang Jian, Xie Jing, Liao Xun. Rapid magnetic solid-phase extraction for the selective determination of isoflavones in soymilk using baicalin-functionalized magnetic nanoparticles. Journal of Agricultural and Food Chemistry, 2013, 61(34), 8072-8078. 

      [18]             Qing Lin-Sen, Xue Ying, Zhang Jian-Guang, Zhang Zhi-Feng, Liang Jian, Jiang Yan, Liu Yi-Ming, Liao Xun. Identification of flavonoid glycosides in Rosa chinensis flowers by liquid chromatography–tandem mass spectrometry in combination with 13C nuclear magnetic resonance. Journal of Chromatography A, 2012, 1249, 130-137. 

      [19]             Qing Lin-Sen, Tang Nan, Xue Ying, Liang Jian, Liu Yi-Ming, Liao Xun. Identification of enzyme inhibitors using therapeutic target protein-magnetic nanoparticle conjugates. Analytical Methods, 2012, 4(6), 1612-1615. 

      [20]             Qing Lin-Sen, Xiong Jing, Xue Ying, Liu Yi-Ming, Guang Bin, Ding Li-Sheng, Liao Xun. Using baicalin-functionalized magnetic nanoparticles for selectively extracting flavonoids from Rosa chinensis. Journal of Separation Science, 2011, 34(22), 3240-3245. 

      [21]             Qing Lin-Sen, Xue Ying, Deng Wen-Long, Liao Xun, Xu Xue-Min, Li Bo-Gang, Liu Yi-Ming. Ligand fishing with functionalized magnetic nanoparticles coupled with mass spectrometry for herbal medicine analysis. Analytical and Bioanalytical Chemistry, 2011, 399(3), 1223-1231. 

      [22]             Qing Lin-Sen#, Shan Xiao-Qing#, Xu Xue-Min, Xue Ying, Deng Wen-Long, Li Bo-Gang, Wang Xiao-Ling, Liao Xun. Rapid probe and isolation of bioactive compounds from Dioscorea panthaica using human serum albumin functionalized magnetic nano-particles (HSA-MNPs)-based ligand fishing coupled with electrospray ionization mass spectrometry. Rapid Communications in Mass Spectrometry, 2010, 24(22), 3335-3339. 

      [23]             Qing Lin-Sen, Xue Ying, Zheng Yi, Xiong Jing, Liao Xun, Ding Li-Sheng, Li Bo-Gang, Liu Yi-Ming. Ligand fishing from Dioscorea nipponica extract using human serum albumin functionalized magnetic nanoparticles. Journal of Chromatography A, 2010, 1217(28), 4663-4668. 

        

      授权专利: 

      [1]   青琳森,丁立生,彭树林,李帮经,梁健.一种黄芪甲苷衍生物及其制备方法和应用,专利号ZL 201611166597.2 (20180814) 

      [2]   青琳森,杨雪锋,丁立生,梁健,饶亮明,李兴德,蒋立银,帅克.一种伏立康唑的合成方法,专利号ZL 201610984653.7 (20190222) 

      [3]   青琳森,王乾龙,杨雪锋,丁立生.山菅兰的活性提取物及其制备方法和应用,专利号ZL 201610187409.8 (20190104) 

      [4]   青琳森,王乾龙,丁立生,梁健,饶亮明,李兴德,蒋立银,帅克.一种牛血清白蛋白检测探针及其制备方法和应用,专利号ZL 201610986773.0 (20180622) 

      [5]   青琳森,廖循,薛莹,熊静,彭树林,丁立生.一种表面键合黄芩苷磁性纳米粒子及其制备方法和用途,专利号ZL 201010545352.7 (20130904)